Overexpression of basic fibroblast growth factor in MCF-7 human breast cancer cells: Lack of correlation between inhibition of cell growth and MAP kinase activation

1998 ◽  
Vol 177 (3) ◽  
pp. 411-425 ◽  
Author(s):  
Robert Wieder ◽  
Eyal Fenig ◽  
Huisheng Wang ◽  
Qin Wang ◽  
Shoshana Paglin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Cell Growth ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Fibroblast Growth ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Kinase Activation ◽  
Mcf 7

The mitogenic signaling pathway for fibroblast growth factor-2 involves the tyrosine phosphorylation of cyclin D2 in MCF-7 human breast cancer cells

FEBS Letters ◽  
2000 ◽  
Vol 478 (3) ◽  
pp. 209-215 ◽  
Author(s):  
Anne-Sophie Vercoutter-Edouart ◽  
Jérôme Lemoine ◽  
Chanel E. Smart ◽  
Victor Nurcombe ◽  
Bénoni Boilly ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7

scholarly journals Effect of Basic Fibroblast Growth Factor on Synthesis/Secretion of pS2 Protein by Human Breast Cancer Cells (MCF-7)

1994 ◽  
Vol 225 (3) ◽  
pp. 1041-1046 ◽  
Author(s):  
Sadakazu Miyashita ◽  
Masao Hirota ◽  
Toshiya Yamamoto ◽  
Chiyoka Shiroyama ◽  
Yoshiko Furukawa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Fibroblast Growth ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7 ◽  
Ps2 Protein

Proteomic Detection of Changes in Protein Synthesis Induced by Fibroblast Growth Factor-2 in MCF-7 Human Breast Cancer Cells

2001 ◽  
Vol 262 (1) ◽  
pp. 59-68 ◽  
Author(s):  
Anne-Sophie Vercoutter-Edouart ◽  
Xavier Czeszak ◽  
Michel Crépin ◽  
Jérôme Lemoine ◽  
Bénoni Boilly ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protein Synthesis ◽  
Growth Factor ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7

scholarly journals Sphingosine Kinase Transmits Estrogen Signaling in Human Breast Cancer Cells

2003 ◽  
Vol 17 (10) ◽  
pp. 2002-2012 ◽  
Author(s):  
Olga A. Sukocheva ◽  
Lijun Wang ◽  
Nathaniel Albanese ◽  
Stuart M. Pitson ◽  
Mathew A. Vadas ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Sphingosine Kinase ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7 ◽  
Cytoplasmic Signaling

Abstract Current understanding of cytoplasmic signaling pathways that mediate estrogen action in human breast cancer is incomplete. Here we report that treatment with 17β-estradiol (E2) activates a novel signaling pathway via activation of sphingosine kinase (SphK) in MCF-7 breast cancer cells. We found that E2 has dual actions to stimulate SphK activity, i.e. a rapid and transient activation mediated by putative membrane G protein-coupled estrogen receptors (ER) and a delayed but prolonged activation relying on the transcriptional activity of ER. The E2-induced SphK activity consequently activates downstream signal cascades including intracellular Ca2+ mobilization and Erk1/2 activation. Enforced expression of human SphK type 1 gene in MCF-7 cells resulted in increases in SphK activity and cell growth. Moreover, the E2-dependent mitogenesis were highly promoted by SphK overexpression as determined by colony growth in soft agar and solid focus formation. In contrast, expression of SphKG82D, a dominant-negative mutant SphK, profoundly inhibited the E2-mediated Ca2+ mobilization, Erk1/2 activity and neoplastic cell growth. Thus, our data suggest that SphK activation is an important cytoplasmic signaling to transduce estrogen-dependent mitogenic and carcinogenic action in human breast cancer cells.

Vitamin D Induced Up-Regulation of Keratinocyte Growth Factor (FGF-7/KGF) in MCF-7 Human Breast Cancer Cells

2000 ◽  
Vol 273 (2) ◽  
pp. 675-680 ◽  
Author(s):  
Alex Lyakhovich ◽  
Nickolai Aksenov ◽  
Pasi Pennanen ◽  
Susanna Miettinen ◽  
Merja H. Ahonen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Growth Factor ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Keratinocyte Growth Factor ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7
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